The area around the Basilica of Saint John the Lateran is less hectic than the historic center or the one near the Termini station, while being quite close, 20 minutes walk from the Colosseum and as much from Santa Maria Maggiore. It is also less touristy. Towards the Colosseum, the hotels and rooms are quite expensive and few (it is the nicest district), while towards Re di Roma on the Appia Nuova or northward on the Esquiline Hill, the establishments are more numerous and a suitable room is usually from about 70 €.
See below the map centered on the Lateran Basilica with hotels and structures, or check out our hotel and room selections: